The creatinine clearance is a measure of the glomerular filtration rate( GFR), which is, the volume of filtrate made by the kidneys per minute. The creatinine clearance is calculated after measuring the volume of urine passed in 24 hours and
the urine and serum creatinine levels. A correction factor is used for body size.
- Normal Values:
male: 97 to 137 ml/min.
female: 88 to 128 ml/min.
Note: ml/min. = milliliters per minute
- Increased creatinine clearance indicates:
- Vigorous Exercise
- Decreased creatinine clearance indicates:
- Renal damage due to drugs like aminoglycosides, cimetidine, cisplatin, and nephrotoxic drugs such as cephalosporins (for example, cefoxitin).
- Acute tubular necrosis
- Congestive cardiac failure
- Acute renal failure
- Bilateral obstructive uropathy
- Chronic renal failure
- End stage renal disease
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