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  Cefazolin

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category First Generation Cephalosporin


Pharmacokinetics

Cefazolin is administered parentrally .It reaches high concentrations in plasma and bile.Cefazolin has a longer half life( 2 hrs )hence used in surgical prophylaxis.80 % is protein bound. 90 % is excreted in the urine.



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Indications

Cefazolin is used in the treatment of infections caused by E.coli, Klebsiella, Staphylococcus Aureus, H.influenza.



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Routes of Administration and Dosage

250 milligrams eighth hourly in milder cases or 1 gm sixth hourly in severe cases I.M or I.V .



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Contra Indications

Cefazolin is contraindicated in pregnancy, lactation, hypersensitivity and during concurrent administration of diuretics.



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Precautions

Precautions are to be taken in Renal disease .



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Interactions

Probenecid increases the blood level of Cefazolin. Concurrent use of diuretic with Cefazolin may increase the nephrotoxicity.



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Brand Names

Alcizon(Alembic), Azolin(Biochem), Cefamezin(Rallis), Cezolin (Lupin), Orizolin(Alidac), Prezolin(Prem Pharma), Prilex(Hindustan), Reflin(Ranbaxy).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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