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  Cefoperazone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Third Generation Cephalosporin


Pharmacokinetics

Cefaperozone is given predominantly Intravenously. It penetrates tissues well. The half life is 2 hrs. 90% is protein bound. 25 % is excreted in urine.Its excretion is reduced in renal impairment. It is metabolised in the liver.



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Indications

Cefoperazone is used in the treatment of infections caused by Staph aureus, salmonella typhi,H. influenzae, Enterobacteria, Ps.aerugenosa, Bacteroides fragilis.It is bactericidal in action.



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Routes of Administration and Dosage

For bacterial infections: For injection dosage form : Adults : 1to 2 grams every twelve hours injected IV.



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Contra Indications

Cefaperozone is contraindicated in hypersensitivity to cephalosporins.



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Precautions

Precaution to be taken in infants less than 1 month.It causes hypoprothombinemia and increases the bleeding tendency.



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Interactions

It enhances the toxicity of Aminoglycosides. It causes Disulfiram like reaction with alcohol.



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Brand Names

Cefomycin(Cadila Healthcare), Lorizin(Dolphin), Magnamycin(Unimed), Megacef(BiologicalE), Myticef( Panacea).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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