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  Ceftizoxime

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Third Generation Cephalosporin


Pharmacokinetics

Ceftizoxime is given parenterally. It is not metabolised in the body and is excreted through the kidneys. Plasma half life is 1.5-2 hours.



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Indications

Ceftizoxime is a third generation cephalosporin that is used in the treatment of meningitis, intra-abdominal infections, respiratory infections, skin and soft tissue infections, bone and joint infections, obstetric and gynaecological infectins. It is active against aerobic gram negative bacteria and some gram gram positive bacteria. Not very active against bacteroides,pseudomonas and staph.aureus.



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Routes of Administration and Dosage

For bacterial infections: For injection dosage form in Adults : 0.5 -1 gms I.M or I.V every eight to twelve hours.



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Contra Indications

Ceftizoxime is contraindicated in renal disease, pregnancy, lactation, infants less than one month of age, and hypersensitivity .



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Precautions

Precautions are to be taken in renal failure, hypersensitivity to penicillins, and pseudomembranous colitis.



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Interactions

Probenicid reduces the renal clearance of Ceftizoxime. Chlorampenicol reduces the drug's activity.



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Brand Names

Cefizox(Burroughs Wellcome), Epocelin(Rallis).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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