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  Ceftriaxone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Third Generation Cephalosporin


Pharmacokinetics

Ceftriazone is a long acting third generation cephalosporin, with half life of 8 hours. It has a good CSF penetration and eliminated equally in urine and bile.



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Indications

Ceftriazone is used in bacterial meningitis[espcially in children], multi-resistant typhoid fever, complicated UTI, abdominal sepsis and septicemia. A single dose of 250 mgs I.M has proved curative in gonorrhea including PPNG.



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Routes of Administration and Dosage

IN meningitis; 4gms followed by 2gms I.V[children 75-100mgs\kg] once daily for 7-10 days. Typhoid; 4gms I.V for 2 days followed by 2 gms\day[for children 75 mgs\kg] till 2 days after the fever subsides.



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Contra Indications

Ceftriazone is contraindicated in patients with hypersensitivity to cephalosporins.



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Precautions

Hypoprothrombinemia and bleeding are specific adverse effects of cephalosporins. Precautions are to be taken in renal failure.



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Interactions

Ceftriazone gives Disulfiram like reaction with alcohol.



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Brand Names

Becef(Alkem), Cefaxone IM(Lupin), Ceftrax(Dee-Pharma), Gramocer(Micro Labs), Gutencef(Merck), Inocef(J.K.Ind), Lyceft(Lyka), MonocefIV(Aristo), Monotax(Biochem), Nosocef(Merind), Odicef(Galpha), Powercef(Wockhardt), Torocef(Torrent), Traxol(Cachet Pharma), Triax( Prem Pharma), Zefone(Cadila Healthcare).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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