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  Cefuroxime

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Second generation cephalosporin.


Pharmacokinetics

Cefuroxime attains higher CSF concentration, hence used in meningitis. It is used parenterally as well as orally.



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Indications

Cefuroxime is active against both gram positive and gram negative bacteria.It is resistant to beta-lactamases. It is used in meningitis caused by H.influenza, meningococci and pneumococci and for therapy of gonorrhea.



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Routes of Administration and Dosage

For bacterial infections: Oral suspension dose in Adults : The oral suspension is usually used only in children. Oral suspension dose in children up to 12 years of age: 10 to 15 milligrams per kilogram of body weight every twelve hours for six to ten days. For tablet dosage form in Adults: 125 to 500 mg every twelve hours. Tablet dosage form in Children up to 12 years of age: 125 mg every twelve hours. For injection dosage form in Adults : 750 mg to 1.5 grams every eight hours IV. For injection dosage form in Children:60mgs/kg/day in 3-4 divided doses.Gonorrhoea is treated with a single dose of 1.5 grams IM, the total 1.5-gram dose is divided into two doses and injected I.M. at two separate places on the body, and given along with a single oral 1 gram dose of Probenecid.



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Contra Indications

Cefuroxime is contraindicated in hypersensitivity to cephalosporins.



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Precautions

Precautions are to be taken in Renal disease, first trimester of pregnancy, during concurrent administration of diuretics and in the elderly.



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Interactions

Few interactions have been reported



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Brand Names

Cefogen(Zeita), Ceftum (Glaxo), Cefuril(J.K.Ind), Fextum(Dee-Pharma), Furoxil(Torrent), Kerozixe(Eli- Lily), Supacef(Glaxo), Zocef(Alkem).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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