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  Chlorpromazine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Central Nervous System
Category Anti-Psychotic(Phenothiazine.)


Pharmacokinetics

Oral absorption is not predictable and bioavailablity is low. Better effects are produced with IM or IV administration. It is highly bound to plasma as well as to tissue proteins. Brain concentration is greater than plasma concentration. It is metabolised in the liver.Plasma half life is around 30 hours. Acute effects of a single dose usually last for 6-8 hours. It has a cumulative effect on chronic administration, so it is possible to give the maintanance dose once a day.



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Indications

Chlorpromazine is used virtually in all types of psychoses. It can be combined with other anti-psychotics. Chlorpromazine is also used to control anxiety or agitation in certain patients,to relieve a wide range of drug or disease induced vomiting, and in severe hiccups. Chlorpromazine is also used in the treatment of tetanus in combination with other drugs.



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Routes of Administration and Dosage

Oral;25-1000 mgs daily, rarely upto 2 gms/day. Parenteral;25-50 mgs I.M 3 or 4 times daily.



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Contra Indications

Chlorpromazine is contraindicated in hepatic disease, parkinson's disease, epilepsy, narrow angle glaucoma and in myasthenia gravis.



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Precautions

Precautions are to be taken in CVS disease, pregnancy, lactation and in elderly patients.



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Interactions

Chorpromazine has additive depressant effect with sedatives, hypnotics, antihistamines, opiates and with alcohol. It potentiates the anti-cholinergic effects of antiparkinson agents and tricyclic-antidepressants, which may lead to a anti-cholinergic crisis. It has additive orthostatic hypotensive effect in combination with MAO inhibitors.



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Brand Names

Chlorpromazine (Rhone-Poulenc), Chlorpromazine Tabs (Sun Pharma), Chlorpromazine Torrent (Torrent), Emetil (LA Pharma), Megatil (Intas), Sun Prazin (Sun Pharma)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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