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  Disopyramide

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Cardiovascular System
Category Antiarrhythmic


Pharmacokinetics

It is completely absorbed when given orally, 70% is excreted by kidney and the rest by the liver.



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Indications

Disopyramide is used to treat ventricular tachyarrythmias and some types of supraventricular arrythmias.



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Routes of Administration and Dosage

For treatment of arrhythmias: For short-acting oral dosage forms (capsules): Adults : 300 milligrams (mg) initially. Then 100 to 150 mg taken every six to eight hours. Children: The dose is usually 6 to 30 mg per kilogram (kg) of body weight per day. This dose is evenly divided and taken every six hours. For long-acting oral dosage forms (extended-release capsules or tablets): Adults: 200 or 300 mg every twelve hours. For injection dosage form: Adults: initially dose is based on body weight . It is usually 2 mg per kg of body weight injected in three divided doses, or, 2 mg per kg of body weight infused over fifteen minutes. Dose following first few doses: It is usually 0.4 mg per kg of body weight per hour given for up to twenty-four hours.



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Contra Indications

Contraindicated in children, AV block, Sick sinus syndrome, Cardiogenic shock, LVF and in Cardiomyopathy.



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Precautions

In Diabetes mellitus : Disopyramide may cause hypoglycaemia. In patients with enlarged prostate : Disopyramide may worsen the symptoms. Glaucoma or Myasthenia gravis : Disopyramide may make these conditions worse. Renal disease or hepatic disease: Effects may be potentiated because of slower removal of Disopyramide from the body.



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Interactions

With Pimozide: Risk of Cardiact arrhythmias may be increased.



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Brand Names

Norpace (Searle).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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