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  Fluoxetine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Central Nervous System
Category Anti-depressant


Pharmacokinetics

It is absorbed moderately well from the gastro-intestinal tract. It is a potent and highly selective serotonin (5HT) uptake inhibitor . It has no affinity for adrenoreceptors, histamine, GABA 'B' or muscarinic receptors.



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Indications

Fluoxetine is used to treat depression. It is also used to treat obsessive-compulsive disorder, bulimia, narcolepsy and cataplexy.



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Routes of Administration and Dosage

Oral dosage:start with 20 milligrams (mg) a day o.d and can be increased upto 80 mgs/day.



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Contra Indications

It is contraindicated in severe renal failure, lactation,hypersensitivity and concomitant use of MAOI's.



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Precautions

Precautions to be taken in patients with epilepsy, liver failure,cardiac disease, diabetes and in pregnancy.



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Interactions

Anticoagulants, digitalis glycosides : Varying blood levels of these drugs or fluoxetine may occur. Central nervous system (CNS) depressants : The CNS depressant effects may be potentiated. Monoamine oxidase (MAO) inhibitors : Taking fluoxetine while taking or within 2 weeks of taking MAO inhibitors may cause confusion, agitation, restlessness, stomach or intestinal symptoms, sudden hyperpyrexia, severe hypertension, and severe convulsions; at least 14 days should be allowed between stopping treatment with an MAO inhibitor and starting treatment with fluoxetine; if the patient has been taking fluoxetine, at least 5 weeks should be allowed before starting treatment with an MAO inhibitor. Phenytoin : Taking this drug with fluoxetine may result in higher blood levels of phenytoin, which increases the chance of serious side effects. Tryptophan: Taking this drug with fluoxetine may result in increased agitation or restlessness and stomach or intestinal problems.



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Brand Names

FLUDAC (ALIDAC), FLUNIL (INTAS), OXEDEP (TORRENT), PLATIN (MERIND), PRODEP (SUN PHARMA)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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