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  Imipramine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Central nervous system
Category Tricyclic anti-depressant


Pharmacokinetics

It is well absorbed orally. It has high protein binding - 90 %.It is extensively metabolized in liver. It is converted in the body to its metabolite desmethyl-imipramine, which is active. About 3 % is excreted in the urine in the form of imino-dibenzylderivatives.



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Indications

It is used in the treatment of depression and nocturnal enuresis.



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Routes of Administration and Dosage

For depression, Oral dose: : 50-100 mg daily. Nocturnal enuresis: 7-11 years; 25-50 mg.Over 11 years; 50-75 mg at bedtime for up to 3 months duration.



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Contra Indications

It is contraindicated in post myocardial infarction states and bundle branch block.



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Precautions

It should be used carefully in patients with glaucoma or enlarged prostrate. In pregnancy the drug crosses the placental barrier and can affect the fetus.



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Interactions

If the drug is administered together with MAOI, it often produces severe reactions similar to atropine poisoning, hyperpyrexia, convulsions and coma. Thyroid preparations may enhance its effects. It can potentiate the action of drugs like phenylephrine, adrenaline and noradrenaline.



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Brand Names

ANTIDEP (TORRENT), DEPRANIL (LA PHARMA), DEPSOL (INTAS), DEPSONIL (SPPL), IMPRAMINE (SUN PHARMA), IMPREL (SIGMA)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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