Welcome, Guest    Sign in to Windows Live ID | Register  

  Industry Medical Portal |  Student Centre |  Sitemap |  Help 
FAQAbout Us |  Disclaimer & Legal |  Contact Us 

  Lactulose

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Gastrointestinal Tract
Category Osmotic Laxative


Pharmacokinetics

Lactulose is a non-absorbable synthetic disaccharide. It is a combination of fructose and lactose. The drug is converted to lactic acid by the gut bacteria, thus increasing the osmotic effect in the intestinal lumen.



Top

Indications

Oral lactulose is given for long-term treatment of chronic constipation. By its osmotic effect it retains water and softens the stool in 3-4 days. It is also has important indication in hepatic encephalopathy, where it reduces the NH3 concentration by 25-50%.



Top

Routes of Administration and Dosage

Oral dose : For Constipation in adults: 10 gms twice daily, adjusted according to patients need. For hepatic encephalopathy: 20-30gms thrice daily, it can be adjusted to produce 2-3 stools per day.



Top

Contra Indications

Lactulose is contraindicated in Galactosaemia, undiagnosed abdominal pain or vomiting, organic constipation like intestinal obstruction, stricture, malignancy or hypercalcaemia. It should also not be used together with drugs that causes constipation like



Top

Precautions

The use of laxatives in Colostomy or Intestinal obstruction or Ileostomy is normally avoided.



Top

Interactions

Use of lactulose along with tetracycline may reduce the effect of tetracycline.



Top

Brand Names

Duphalac(Duphar-Interfran), Lacsan(Unique), Livoluk(Panacea).



Top

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

|

 

Advertisement
Tell us what you think about Web Health Centre - Send us your feedback
Copyright © 2015 WebHealthCentre. All rights reserved. Brought to you by