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  Lorazepam

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Central nervous system
Category CNS Depressant (Benzodiazepine. )


Pharmacokinetics

Lorazepam is moderately rapidly absorbed from the proximal small intestine. It is extensively distributed in the body. It is transformed to clinically acive metabolites. It has a moderately long half-life[10-20 hours] and may persist in the body . It is metabolised in the liver. Clearance is reduced in liver damage.



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Indications

Lorazepam is used as a first line drug in status epilepticus. It is also used in anxiety states and in psychosomatic disorders.



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Routes of Administration and Dosage

Oral:1-4 mgs daily in divided doses. For status epilepticus: 4 mgs I.V bolus, repeated again if necessary. In children the dose is 0.05-0.2 mgs/kg.



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Contra Indications

Lorazepam is contraindicated in patients hypersensitive to benzodiazepines and in neonates.



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Precautions

Precaution has to be taken in severe hepatic&renal dysfunction, acute narrow angle glaucoma, pulmonary insufficiency and children below 6 years of age.



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Interactions

Lorazepam potentiates the effects of other CNS depressants.



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Brand Names

ATIVAN (WYETH LEDERLE), CALMESE (THEMIS CHEMICALS), LARPOSE (CIPLA), TRAPEX ( SUN PHARMA), ZEPNAP (LA PHARMA)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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