Short-acting oral dose (capsules, oral solution, syrup, or tablets): For severe, chronic pain in Adults: initially 10 to 30 milligrams (mg) every four hours. For injection dosage form: For pain in Adults: 5 to 20 mg (usually 10 mg), injected IM or SC every four hours as needed. It can also be given as 4 to 10 mg, injected slowly as IV. Children: 0.1 to 0.2 mg per kg of body weight, up to a maximum of 15 mg, injected SC every four hours as needed. It can also be administered as 0.05 to 0.1 mg per kg of body weight, injected slowly as IV.

Morphine is contraindicated in respiratory depression, hypersensitivity, paralytic ileus, delayed gastric emptying, Obstructive airway disease, acute hepatic disease, MAO Inhibitor administration, pregnancy, lactation and in children.

Precautions

Some of the adverse effects of morphine can be dangerous in CNS disease, head injury, Emphysema, asthma, chronic lung disease, enlarged prostate and in micturition difficulties. The chance of adverse effects may be increased in Colitis, cardiac disease, renal disease and in Hepatic disease.

Interactions

Morphine will not be effective in people taking naltrexone. It can increase the sedative effect of alcohol, increase the risk of respiratory depression when used with MAO inhibitors and Cimetidine. It antagonises the effects of diuretics.

Brand Names

Morcontin(Modi Mundipharma), Morphine HcL(BDH)

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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