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  Oxazepam

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Central nervous system
Category Benzodiazepine.


Pharmacokinetics

Oxazepam is slowly absorbed from the gut, and the CNS penetration is also slow. It's plasma half life is about 10 hours. It has no active metabolites-the duraton of action is relatively shorter. The hepatic metabolism is not significant, hence prefered in elderly and in those with hepatic disease.



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Indications

Oxazepam is used to relieve the anxiety, tention, agitation, and irritability in the elderly and in those with hepatic disease.



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Routes of Administration and Dosage

Oral dose:30-60 mgs in 2-3 divided doses.



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Contra Indications

Oxazepam is cotraindicated in children under 6 years, hypersensitivity, acute pulmonary insufficiency, and in psychosis.



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Precautions

Precaution has to be taken in myasthenia gravis, acute narrow angle gaucoma, and in pregnancy & lactation.



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Interactions

Oxazepam potentiates the CNS depression produced by other drugs[alcohol, babiturates, MAO inhibitors].



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Brand Names

SEREPAX (WYETH LEDERLE)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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