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  Quinidine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Cardiovascular System
Category Antiarrhythmic and Anti malarial


Pharmacokinetics

It is completely absorbed from the GIT and is primarily metabolised in the liver and excreted by the kidney in the urine.



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Indications

Quinidine is used to correct cardiac arrhythmiaa and to reduce tachycardia . The injection dosage form is also used to treat malaria. Quinidine acts directly on the heart tissues to make them less responsive. It also slows impulses along conduction bundles in the heart. This allows the heart to work more efficiently.



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Routes of Administration and Dosage

For regular (short-acting) oral dose: For arrhythmias: Adults: 200 to 650 milligrams (mg) two to four times a day. Children : 6 to 8.25 mg per kilogram (kg) of body weight five times a day.For long-acting oral dosage forms: For arrhythmias: Adults: 300 to 660 mg every six to twelve hours. For injection dosage form: For arrhythmias: Adults: 400 to 600 mg injected into the muscle every two hours or 600 to 800 mg in a solution and injected into a vein. For malaria: Adults: 10 mg per kg of body weight in a solution and injected slowly into a vein over one to two hours. Then, 0.02 mg per kg of body weight per minute is given. Or, 12 to 24 mg per kg of body weight in a solution and injected slowly into a vein over a four hour period every eight hours.



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Contra Indications

Contraindicated in heart block, myasthenia gravis, thrombocytopenia, prolonged AT interval and digitalis intoxication.



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Precautions

Precaution to be taken are in Asthma or emphysema: Possible allergic reaction. Blood disorders, Infection, renal disease or hepatic disease: Effects may be potentiated because of slower removal of quinidine from the body. Myasthenia gravis: Muscle weakness may be increased. Precuations must alos be taken in hyperthyroidism and psoriasis.



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Interactions

With Anticoagulants : Risk of bleeding may be increased. Digoxin: cardiac effects may be increased. Pimozide : Risk of cardiac arrhythmias may be increased. Urinary alkalizers: such as acetazolamide, calcium or magnesium-containing antacids, dichlorphenamide, methazolamide, potassium or sodium citrate or citric acid, sodium bicarbonate: Effects of the drug may be potentiated because levels of quinidine in the body may be increased.



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Brand Names

Natacardine (Franco Indian), Quinidine (Burroughs Wellcome).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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