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  Ranitidine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Gastro-Intestinal System
Category H2-receptor antagonists


Pharmacokinetics

It is well absorbed orally, but its bioavailablity is reduced when given with antacids. Theraupetic effect lasts for about 4-7 hours. It is excreted mainly in the urine, within 24 hours mainly as unchanged drug. It can cross the placental barrier and is secreted in milk.



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Indications

Ranitidine belongs to the class Histamine H2-receptor antagonists, known also as H2-blockers, which are used to treat duodenal ulcers and prevent their recurrence. They are also used to treat gastric ulcers and for some conditions, such as Zollinger-Ellison syndrome. These drugs are used to relieve and prevent heartburn, acid indigestion, and stomach hyperacidity.



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Routes of Administration and Dosage

Oral: 150 mgs bd or 300 mgs at bed time. Parenteral: 50 mgs I.M or slow I.V. Rapid I.V injection can cause hypotention.



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Contra Indications

H2-blockers may be contraindicated in : Renal disease, hepatic disease: the H2-blocker may build up in the bloodstream, which increases the risk of side effects. Immunodeficiency : Decrease in stomach acidity caused by H2-blockers may increase the risk



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Precautions

Allergies : Allergies to Ranitidine may occur. Pregnancy : H2-blockers have not yet been fully studied in pregnant women. Breast-feeding : Ranitidine passes into the breast milk and may cause adverse effects, such as decreased amount of stomach acid and increased excitement, in the nursing baby. . Adults : Confusion and dizziness may be especially likely to occur in elderly patients, who are usually more sensitive than younger patients.



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Interactions

Aminophylline, Anticoagulants, Caffeine, Metoprolol, Oxtriphylline, Phenytoin, Propranolol, Theophylline, Tricyclic antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline ) : these drugs when used with ranitidine have been shown to potentiate the effects of ranitidine. Itraconazole, Ketoconazole : H2-blockers may decrease the effects of itraconazole or ketoconazole, hence H2-blockers should be taken at least 2 hours after these drugs.



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Brand Names

ACILOC (CADILA PHARMA), ADVENE (KNOLL PHARMA), RANITIDINE (GLAXO), RANTAC(UNIQUE), ZINETAC(GLAXO)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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