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  Streptomycin

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Aminoglycoside Antibiotic


Pharmacokinetics

Streptomycin is poorly absorbed from GIT hence administered intramuscularly. It reaches a peak concentration in 1/2 to1 hour. It is mainly concentrated in the liver, kidneys and in skeletal muscles. It is excreted mainly in the unchanged form via urine and a part is metabolised in the liver.



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Indications

Streptomycin is active against M.Tuberculosis, Shigella, Proteus, Pseudomonas, H.Influenza, Brucella, Listeria and Nocardia.



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Routes of Administration and Dosage

For all dosage forms: Treatment of tuberculosis (TB) in Adults: 1 gram injected IM once a day. This will be reduced to two or three times a week, if possible. Children: 15-20 mg/kg/day. For treatment of bacterial infections in Adults: 250 milligrams to 1 gram of streptomycin is injected IM every six to twelve hours. Children: Dose is based on body weight and is injected IM every six to twelve hours.



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Contra Indications

Streptomycin is contraindicated in renal impairment and in lactation.



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Precautions

In Myasthenia gravis or Parkinson's disease, Aminoglycosides may aggravate the problems, resulting in further muscle weakness. High streptomycin blood levels may cause hearing loss or equilibrium disturbances (ototoxicity)..



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Interactions

Use of Lithium, Methotrexate, Penicillamine, Quinine, Streptozotocin, Tiopronin with aminoglycosides may increase the chance of ototoxicity and renal disorders.



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Brand Names

Ambistryn-S(Sarabhai), SM-750(Plethico).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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