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  Tinidazole

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Antiprotozoal agent-Nitroimidazole group


Pharmacokinetics

Tinidazole has a longer half life than Metronidazole and is better tolerated. Its t1/2 is greater than 12 hrs, hence used for single dose therapy. It is metabolised in the liver through glucuronidation and Oxidation and is excreted in the urine.



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Indications

Tinidazole is given for treatment of protozoal infections like amoebiasis, giardiasis, trichomoniasis . It is also used in the treatment of anaerobic infections.



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Routes of Administration and Dosage

For oral dosage form: For Amoebiasis in adults: 2gms once daily for 3 days, in children 30-50mgs/kg/day for 3 days. For giardiasis and trichomoniasis: 2gms single dose or 0.6gm once daily for 7 days. For anaerobic infection : Prophylactic in adults: 2gms



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Contra Indications

Tinidazole is contraindicated in blood dyscrasias, active neurological diseases and in first trimester of pregnancy.



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Precautions

Precaution has to be taken in late trimesters of pregnancy, seizure disorders, in hepatic and renal impairment and in alcoholics.



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Interactions

Tinidazole increases the risk of bleeding when combined with anticoagulants. When the drug is taken along with alcohol, disufiram like reaction occurs. Enzyme inducers ( phenobarbitone, rifampicin ) and cimetidine can reduce the metabolism of tinidazole.



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Brand Names

Amebamagma(Wyeth Lederle), Anabac(Camlin), Camitol(Camlin), Costini(CFL), Enidazol(East India), Fasigyn(Pfizer), Nida(Alpine0, Tina 1000, 300, 500( Bombay tablets), Tindol(Samil Remedies), Tini(Kopran), Tini DS(Kopran), Tiniba(Cadila Healthcare), Tiniba Infusion( Alidac), Tiniba P.P(Alidac), Tinicide DS(Blue Cross), Tinidafyl(Jagsonpal), Tinipidi I.V(Parenetral Drugs0, Tizole(Dolphin), Trag(Walter Bushnell), Tridazole (Franco- Indian), Zil (Sarabhai), Zoacide(Tata Pharma).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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