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  Urokinase

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Cardiovascular System
Category Thrombolytic/Plasminogen Activator


Pharmacokinetics

It directly converts plasminogen to active plasmin.



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Indications

Thrombolytic agents are used to dissolve thrombii that have formed in certain blood vessels. These drugs are usually used when a thrombus seriously lessens the flow of blood to certain parts of the body. Thrombolytic agents are also used to dissolve thrombii that form in catheters and tubes that are placed into the body. The tubes allow treatments such as dialysis or injections into a vein to be given over a long period of time.



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Routes of Administration and Dosage

It requires a loading dose of 300,000 units given over a period of 10 mins and a maintenance dose of 300,000 units for 1 hrs.



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Contra Indications

Contraindicated in Hypersensitivity, bleeding diathesis, trauma.



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Precautions

Allergies: Allergic reaction to Urokinase may occur. Pregnancy :There is a slight chance that use of a thrombolytic agent during the first five months of pregnancy may cause a miscarriage. Older adults: The need for treatment with a thrombolytic agent may be increased in elderly patients with blood clots, however, the chance of bleeding may also be increased.



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Interactions

Aspirin, Cefamandole, Divalproex, Enoxaparin, Heparin, Indomethacin, anti-inflammatory drugs or analgesics (except narcotics), Phenylbutazone, Plicamycin, Sulfinpyrazone, Ticlopidine or Valproic acid: when used together with Urokinase increases the chances of bleeding .



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Brand Names

Dabunase (Dabur), Kd-Unase (VHB), Urokinase (TTK).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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