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  Vitamin B6 (Pyridoxine)

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General Systemic
Category Water soluble vitamin.


Pharmacokinetics

The vitamin is absorbed well from the intestines. It is oxidized in the body and excreted as pyridoxic acid. Very small amounts only are stored in the body.



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Indications

It is used prophylactically in infants with difficiency of other B Complex vitamins.Pyridoxine is used to prevent and treat isoniazid, hydralazine and cycloserine induced neurological disturbances. Pyridoxine responsive anemia and homocystinuria are rare genetic disorders that are benefitted by large doses of pryidoxine. It is also used to treat mental symptoms in women on oral contraceptives



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Routes of Administration and Dosage

Prophylatically: Infants with deficiency disorders = 2-5 mg/day. To treat drug induced neurological disturbances = 10-50 mg/day. To treat mental symptoms in women taking oral contraceptives = 50 mg/day. To treat Pyridoxine resistant anaemia and homocysti



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Contra Indications

It is a relatively safe drug and may rarely cause adverse effects.



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Precautions

Prolonged intake of large doses can lead to dependence and sensory neuropathy.



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Interactions

Isoniazid inhibits generation of pyridoxal phosphate and increases excretion of pyridoxine compounds. Hydralazine, cycloserine and penicillamine interfere with pyridoxine utilisation. Pyridoxine prevents dopamine from being effective in the treatment of parkinsonism.



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Brand Names

PYRIDOXINE HYDROCHLORIDE.



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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