The vitamin is absorbed well from the intestines. It is oxidized in the body and excreted as pyridoxic acid. Very small amounts only are stored in the body.
It is used prophylactically in infants with difficiency of other B Complex vitamins.Pyridoxine is used to prevent and treat isoniazid, hydralazine and cycloserine induced neurological disturbances. Pyridoxine responsive anemia and homocystinuria are rare genetic disorders that are benefitted by large doses of pryidoxine.
It is also used to treat mental symptoms in women on oral contraceptives
Routes of Administration and Dosage
Prophylatically: Infants with deficiency disorders = 2-5 mg/day. To treat drug induced neurological disturbances = 10-50 mg/day. To treat mental symptoms in women taking oral contraceptives = 50 mg/day. To treat Pyridoxine resistant anaemia and homocysti
It is a relatively safe drug and may rarely cause adverse effects.
Prolonged intake of large doses can lead to dependence and sensory neuropathy.
Isoniazid inhibits generation of pyridoxal phosphate and increases excretion of pyridoxine compounds. Hydralazine, cycloserine and penicillamine interfere with pyridoxine utilisation. Pyridoxine prevents dopamine from being effective in the treatment of parkinsonism.
Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names