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  Vitamin D

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Vitamin.


Pharmacokinetics

It is absorbed well from the intestines in the presence of bile-salts. Absorption of D3 is better than D2. It is bound to a specific alpha-globulin in the circulation and is stored mainly in the adipose tissue for many months. It is hydroxylated in the liver and the metabolites are mainly excreted in the bile.



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Indications

Vitamin D is used to treat conditions in which calcium is not used properly by the body[eg:obtructive jaundice, steatorrhoea...etc]. Ergocalciferol is the form of vitamin D used in vitamin supplements. In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have vitamin D deficiency, hence supplements are given. It is used in metabolic rickets, senile or postmenopausal oateoporosis and in hypoparathyroidism.



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Routes of Administration and Dosage

Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia . Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with renal disease in patients



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Contra Indications

It may be contraindicated in: Cardiac disease: Alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol may cause hypercalcemia which may make these conditions worse. Renal disease : High blood levels of alfacalcidol, calcifediol, calcitriol, dihydr



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Precautions

Hypersensitivity reactions to the drug may occur. Precautions must be taken when taking the drug during pregnancy and breast-feeding.



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Interactions

Antacids containing magnesium : Use of these products with any vitamin D-related compound may result in high blood levels of magnesium, especially in patients with renal disease. Calcium-containing preparations or Thiazide diuretics : these preparations with vitamin D may cause hypercalcemia and increase the chance of adverse effects. Other Vitamin D related compounds: Use of vitamin D with a related compound may cause hypercalcemia.



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Brand Names

ALFACIP[Cipla]: ALPHADOL[Panacea].



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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