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  Amiodarone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Cardiovascular System
Category Antiarrhythmic


Pharmacokinetics

It has a long half life,hence a single dose is enough, as blood levels are maintained due to low metabolism in the body



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Indications

Amiodarone belongs to the group of drugs known as Class III antiarrhythmics. It is used to correct Cardiac arrhythmias . Amiodarone produces its therapeutic effects by slowing nerve impulses in the heart and acting directly on the cardiac tissue .



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Routes of Administration and Dosage

For oral dosage form (tablets): For treatment of ventricular arrhythmias: Adults: At first, 800 to 1600 milligrams (mg) per day taken in divided doses. Then, 600 to 800 mg per day for one month. Then, 400 mg per day. Children: The dose for the first ten days is usually 10 mg per kilogram of body weight per day. Then, the dose is decreased to 5 mg per kilogram of body weight per day. After several weeks, the dose is then decreased to 2.5 mg per kilogram of body weight per day.



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Contra Indications

Contraindicated in Sick Sinus Syndrome, 2nd and 3rd degree AV block, pregnancy, lactation, thyroid disease, and previous toxic effect.



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Precautions

Allergies: Allergic reactions may occur during the use of amiodarone. Pregnancy : Amiodarone has been shown to potentiate thyroid effects in babies whose mothers took amiodarone when pregnant. In addition, there is concern that amiodarone could cause bradycardia in the new born. Breast-feeding: Although amiodarone passes into breast milk, it has not been shown to cause problems in nursing babies. Older adults: Elderly patients may be more likely to have thyroid effects with this drug. Also, unstable gait, numbness, tingling, trembling, or weakness in hands or feet are more likely to occur in the elderly.



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Interactions

It reduces the clearance of Anticoagulants, quinidine, Phenytoin, Procainamide and their effects may be increased.



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Brand Names

Aldarone (Alidac), Amiodarone HCL-Chile (Shree Ganesh), Cordarone (Torrent), Eurythmic (Troikaa).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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