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  Cefamandole

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions


Systems General (Systemic)
Category Second Generation Cephalosporin


Pharmacokinetics

Cefamandole attains high concentration in bile and is excreted in the urine as such .



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Indications

Cephamandole is more effective against gram negative organisms including Enterobacter, Klebsiella and Proteus and less active against Gram positive organisms than first generation Cephalosporins .



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Routes of Administration and Dosage

For bacterial infections: Injection dose: Adults: 500 milligrams (mg) to 2 grams every four to eight hours, injected IV or IM.



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Contra Indications

Cefamandole is contraindicated in pregnancy, lactation and hypersensitivity to cephalosporins.



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Precautions

Precautions are to be taken in Renal disease when the dose of the drug needs to be reduced and when diuretics are used concurrently.



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Interactions

Probenecid may increase the blood level of Cefamandole. Concurrent use of diuretic with Cefamandole may increase the nephrotoxicity.



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions

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